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Breast cancer (BC) is the most common cancer to be diagnosed in more than 100 nations and is the main reason why most women die from cancer. This article mainly reviewed the breast cancer in the worldwide and emphasizes on the burden of BC in developing countries. Different developing nations like Nigeria, Jordan, Fiji Islands, Bangladesh, Afghanistan, India, Pakistan, South Africa, Brazil, China etc. have shown higher death rates and their women are struggling highly with BC due to many factors: economically instability, poor infrastructure and unawareness. The incidence and mortality rates of respective regions and countries are described with comparison between developed and developing countries. In conclusion, there are various ways to detect and diagnose BC and reasons to show their dominance in certain regions of the world.